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PUBLIC COMMENTS CLOSE AUGUST 7, 2026 AT 11:59 P.M. ET

Save Tianeptine

DEA Proposed Rule • Docket DEA1596

Stop Tianeptine From Going Into Schedule I

DEA is proposing permanent Schedule I placement for tianeptine. That would impose the nation's strictest controlled-substance restrictions on a medication prescribed in other countries, create new barriers to research, and expose possession to federal criminal sanctions. Tell DEA to choose an evidence-based and proportionate path.

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Comment deadline
11:59 p.m. Eastern Time on August 7, 2026
Federal Register
91 FR 42150 • Doc. 2026-13821
Comment document ID
DEA-2026-1091-0002

What DEA is proposing

In a notice of proposed rulemaking published on July 8, 2026, the Drug Enforcement Administration, Department of Justice proposed to place tianeptine permanently in Schedule I of the Controlled Substances Act. The proposal covers tianeptine and its specified isomers, esters, ethers, salts, and related salts.

This is not a proposal to restrict retail sales, require a prescription, set manufacturing standards, or impose age limits. Schedule I is the most restrictive federal category, reserved for substances treated as having no currently accepted medical use in the United States.

If finalized, Schedule I controls and sanctions would apply to activities including manufacture, distribution, import, export, research, chemical analysis, and possession.

Why Schedule I matters

  • Patients and the public

    A Schedule I rule would not distinguish between problematic commercial products and the underlying molecule.

  • Science and research

    Researchers handling Schedule I substances face additional registrations, controls, storage requirements, and administrative burdens.

  • Medical evidence

    The proposal concerns a substance that has been used as a prescription medication outside the United States and has been studied in humans.

What the campaign is asking for

Regulation is not the same as prohibition.

Three ways to act

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Opposing Schedule I Does Not Mean Ignoring Risk

Tianeptine can be misused, and products sold with inaccurate labels or unsupported medical claims can cause serious harm. The question before DEA is not whether risks exist. The question is whether permanent Schedule I prohibition is scientifically justified, proportionate, and protective of patients and research. This campaign supports enforceable product regulation and public-health safeguards—not an unregulated market.

Your experience belongs in the public record.

Federal regulatory comments are generally public. Do not include information you do not want publicly displayed. This website does not provide medical or legal advice.

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